As connectivity to the industrial network grows, the number and type of devices– smart sensors, valves, and gauges – expands the attack surface making industrial environments low-hanging fruit for an attack. Cyber physical systems can be difficult to defend due to the mix of modern and legacy equipment. Cloud adoption, and the introduction of Artificial Intelligence (AI) and Machine Learning (ML), have increased to improve data analytics and support the growing need for remote access. As headlines highlight, attackers are recycling old threats using new techniques with industrial organizations in their sites. This panel of OT experts will discuss the threats, challenges, and strategies to secure cyber physical systems including cloud connectivity, AI / ML, 5G and industrial IoT.